Pediatr. praxi. 2008;9(3):181-186

The treatment with growth hormone in childhood

doc. MUDr. Ąudmila Koą»álová CSc
II. Detská klinika, LF UK a Detská fakultna nemocnica s poliklinikou, Bratislava

The treatment with recombinant growth hormone started in Slovakia in 1992. The first indication was a deficit of growth hormone in childhood, later on the indications broadened to the use of growth hormone in children with Turner syndrome and children who have growth retardation and have chronic renal failure. New evidence about metabolic effect of growth hormone as a neurotransmitter lead to its use in the treatment of children with Prader-Willy syndrome and in adults with a heavy deficit of growth hormone, especially after surgeries on adenohypophysis or in patients with persistent deficit of growth hormone since childhood. Last two years children born with low birth weight and/or length and persistent growth retardation were also treated in Slovakia. The author discusses in the article diagnostic criteria for treatment initiation in individual diagnosis, side effects of the treatment as well as monitoring of patients on treatment with growth hormone.

Keywords: growth hormone, treatment with growth hormone, indications of treatment, monitoring of treatment with growth hormone, deficit of growth hormone

Published: August 1, 2008  Show citation

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Koą»álová Ą. The treatment with growth hormone in childhood. Pediatr. praxi. 2008;9(3):181-186.
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References

  1. Bacheré N, Diene G, Delagnes V, Molinas C, Moulin P, Tauber M. Early diagnosis and multidisciplinary care reduce the hospitalization time and duration of tube feeding and prevent early obesity in PWS infants. Horm Res, 2008; 69(1): 45-52. Go to original source... Go to PubMed...
  2. Eiholzer U. Deaths in children with Prader-Willi syndrome. A contribution to the debate about the safety of growth hormone treatment in children with PWS. Horm Res, 2005; 63(1): 33-39. Go to original source... Go to PubMed...
  3. Ergun-Longmire B, Merters A, Mitby P et al. Growth hormone treatment and risk of second neoplasia in the childhood cancer supervisor. J Clin Endocrinol Metab, 2006; 91(10): 3494-3498. Go to original source... Go to PubMed...
  4. Ferrez Collett-Soldberg P, Petryk A et al. Chages in recombinant human growth hormone (rhGH) prescribing information. The drugs and therapeutics committee of the Lawson Wilkins Pediatric Endocrine Society, Toronto, 2007, www.accessdata.fda.gov/ scripts/cder/drugsatfda/index.cfm.
  5. GH Research Society: Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: Summary statement of the GH Research Society. J Clin Endocrinol Metab, 2000; 85(11): 3990-3993. Go to original source...
  6. Guidance on the use of human growth hormone (somatropin) in children with growth failure. National Institute for Clinical Excellence, London, 2005. www.nice.org.uk.
  7. Hokken-Koelega A. Growth hormone therapy in children with Prader-Willi Syndrome. Endocrine abstracts of the 10th European Congress of Endocrinology, 2008, 16, abstr. č. S15.3.
  8. Chatelain P, Carrascosa A, Bona G, Ferrandes-Longas A, Sippell W. Growth hormone therapy for short children born small for gestational age. Horm Res, 2007; 68(6): 300-309. Go to original source... Go to PubMed...
  9. Mayers SE, Whitman BY, et al. Two years of growth hormone therapy in young children with Prader-Willi syndrome: Physical and neurodevelopmental benefit. Am J Med Genet, 2006, Part A, 143 A (11): 443-448. Go to original source... Go to PubMed...
  10. Zapletalová J, Lebl J, ©najderová M et al. Turnerův syndrom. Praha: Galén, 2003, s. 207.




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