Pediatr. praxi. 2009;10(2):76-79

Macrolide antibiotics in paediatric practice

prof. MUDr. Jiří Havlík DrSc1,2
1 Emeritní profesor I. infekční kliniky 2. LF UK, FN Na Bulovce, Praha
2 I. infekční klinika 2. LF a Katedra infekčních nemocí IPVZ, Praha

Natural macrolide antibiotics are gradually replaced by semisynthetic preparations with superior properties. While having comparable

antimicrobial action, the latter require lower single doses and longer dosage intervals, are better tolerated by the paediatric population,

and induce adverse effects less frequently. Inappropriate selection of antibiotics, incorrect dosage, and improper indications, however,

increase the risk of increasing resistance in common bacterial pathogens. Macrolides are excellent drugs for ambulatory practice. For

them to remain effective, treatment needs to be initiated for properly indicated infections, correct dosage needs to be chosen, and

dosage intervals as well as duration of treatment determined.

Keywords: natural macrolides, semisynthetic macrolides, azalides, ketolides.

Published: April 1, 2009  Show citation

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Havlík J. Macrolide antibiotics in paediatric practice. Pediatr. praxi. 2009;10(2):76-79.
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    References

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