Pediatr. praxi. 2011;12(4):267-269

Acute methemoglobinemia - serious alimentary intoxication caused by vegetable

MUDr.Kateřina Pizingerová, Ph.D.1, MUDr.Jiří Fremuth1, MUDr.Lumír Šašek1, prof.MUDr.Josef Sýkora, Ph.D.1, MUDr.Zdeňka Černá1, MUDr.Alice Hrušková1, MUDr.Renata Pomahačová, Ph.D.1, MUDr.Zdeňka Baliharová2, RNDr.Svatopluk Krýsl, CSc.3, MUDr.Vlasta Petříková4, doc.MUDr.Jiří Kobr, Ph.D.1
1 Dětská klinika LF UK a FN, Plzeň
2 PLDD, Plzeň
3 Zdravotní ústav se sídlem v Plzni, Centrum hygienických laboratoří, Klatovy
4 Ústav klinické biochemie a hematologie LF UK a FN, Plzeň

Authors present a case report of a 2-year-old male who developed acute intoxication caused by nitrates following a large amount of

ingested uncooked pumpkin. Clinical signs included partial loss of consciousness, vomiting and cyanosis. The level of methemoglobin

reached > 0,3 (> 30 %). This condition required urgent tracheal intubation, artificial lung ventilation using 100 % oxygen and administration

of antidote. Complete treatment was effective and led to the full-recovery of the patient. The definitive evidence of the cause of the

condition was difficult, nevertheless convincing. The authors inform the medical community about dangerous alimentary intoxication

of children who are fed seemingly healthy vegetables from unchecked origins.

Keywords: acute methemoglobinemia, nitrates intoxication, unregulated vegetable markets

Published: September 2, 2011  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Pizingerová K, Fremuth J, Šašek L, Sýkora J, Černá Z, Hrušková A, et al.. Acute methemoglobinemia - serious alimentary intoxication caused by vegetable. Pediatr. praxi. 2011;12(4):267-269.
Download citation

References

  1. Chan TYK. Vegetable-borne nitrate and nitrite and risk of methaemoglobinaemia. Toxicology Letters 2011; 200: 107-108. Go to original source... Go to PubMed...
  2. Bloom J. Comprehensive Toxicology. Amsterdam, Netherlands: Elsevier, 1997; 4: 62-66.
  3. Marcus S. Poison centers' perspective. Public Health Rep. 1998; 113(5): 379-380.
  4. Hoffman R, Benz E, Shattil S, et al. Hematology Basic Principles and Practice. 4th ed. New York, NY: Churchill Livingstone 2005; 650-657.
  5. do Nascimento TS, Pereira RO, de Mello HL, Costa J. Methemoglobinemia: from diagnosis to treatment. Rev Bras Anestesiol. 2008; 58(6): 651-664. Go to original source... Go to PubMed...
  6. Mansouri A, Lurie AA. Concise review: methemoglobinemia. Am J Hematol. 1993; 42(1): 7-12. Go to original source... Go to PubMed...
  7. Friedmann B. Hematologie v praxi. Praha: Galén, 1994; 121-122.
  8. Černá Z. Krevní nemoci a nádory. In Stožický F, Pizingerová K, a kol. Základy dětského lékařství. Praha: Karolinum, 2006; 260.
  9. Grauer SE, Giraud GD. Toxic methemoglobinemia after topical anesthesia for transesophageal echocardiography. J Am Soc Echocardiogr. 1996; 9(6): 874-876. Go to original source... Go to PubMed...
  10. Ash-Bernal R, Wise R, Wright SM. Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals. Medicine (Baltimore) 2004; 83(5): 265-273. Go to original source... Go to PubMed...
  11. Simon C, et al. Z. Kinderheilk 1964; 91: 124. Go to original source...
  12. Hord NG, Tang Y, Bryan NS. Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am J Clin Nutr 2009; 90: 1-10. Go to original source... Go to PubMed...
  13. Kübler W. Importace of nitrate content of vegetables in infant nutrition. Z Kinderheilk, 1958; 81: 405-416. Go to original source... Go to PubMed...
  14. Sanches-Echaniz J, Benito-Fernández J, Mintegui-Raso S, Methemoglobinemia and consumption of vegetables in infant. Pediatrics 2001; 107: 1024-1028. Go to original source... Go to PubMed...
  15. Sinios VA, Wodsak W. Die Spinatvergiftung des Säuglings. Dtsch Med Wocheschr 1965; 90: 1856-1863. Go to original source... Go to PubMed...
  16. EFSA Panel on Contaminants in the Food Chain (CONTAM). Statement on possible public health risks for infants and young children from the presence of nitrates in leafy vegetables. EFSA Journal 2010; 12: 1935, 1-42.
  17. Curry S. Methemoglobinemia. Ann Emerg Med 1982; 11(4): 214-221. Go to original source... Go to PubMed...
  18. Goluboff N, Wheaton R. Methylene blue induced cyanosis and acute hemolytic anemia complicating the treatment of methemoglobinemia. J Pediatr. 1961; 58: 86-89. Go to original source... Go to PubMed...
  19. Turner MD, Karlis V, Glickman RS. The Recognition, Physiology, and Treatment of Medication-Induced Methemoglobinemia: A Case Report. Anesth Prog. 2007; 54(3): 115-117. Go to original source... Go to PubMed...
  20. Murone AJ, Stucki P, Roback MG, Gehri M. Severe methemoglobinemia due to food intoxication in infants. Pediatr Emerg Care 2005; 21(8): 536-538. Go to original source... Go to PubMed...
  21. Verive MJ, Coppes MJ. Pediatric Methemoglobinemia. http://emedicine.medscape.com/aerticle/956528-treatment. 2009.




Pediatrics for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.