Pediatr. praxi. 2014;15(1):22-24

Allergen-specific immunotherapy in children

doc.MUDr.Vít Petrů, CSc.
Centrum alergologie a klinické imunologie, Nemocnice Na Homolce, Praha

Allergen-specific immunotherapy is the only effective causal treatment that can modify the natural history of allergic diseases and

induce allergen-specific immune tolerance in children and adults. It is highly effective in IgE-mediated diseases as in allergic rhino-

-conjunctivitis and allergic asthma and in patients who develop systemic anaphylactic reactions to wasp/bee venom. In current clinical

practice immunotherapy is delivered either subcutaneous or sublingually. Allergen administrations may bee associated with local, and

in some cases, even systemic allergic side-effects. The development of allergen vaccines in drops and tablets for sublingual application

has opened a new age of more convenient and safer form of immunotherapy, in children above all.

Keywords: allergy in children, allergen-specific immunotherapy

Published: February 15, 2014  Show citation

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Petrů V. Allergen-specific immunotherapy in children. Pediatr. praxi. 2014;15(1):22-24.
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    References

    1. Noon L. Prophylactic inoculation against hay fever. Lancet 1911; 1: 152-115. Go to original source...
    2. Alvarez-Cuesta E, Bousquet J, Canonica GW, et al. Standards for practical allergen-specific immunotherapy. EAACI Immunotherapy Task Force, Allergy 2006; 61(Suppl 82): 1-20. Go to original source... Go to PubMed...
    3. Špičák V. Imunoterapie a imunomodulace. In: Petrů V, a kol. Dětská alergologie. Praha: 2012: 142-152.
    4. Jutel M, Akdis CA. Immunological mechanisms of allergen-specific immunotherapy. Allergy 2011; 66(6): 725-732. Go to original source... Go to PubMed...
    5. Bousquet J, Lockey R, Malling HJ. WHO possition paper. Allergen immunotherapy: Therapeutic vaccines for allergic diseases. Allergy 1998; 53(Suppl. 54): 1-42. Go to original source... Go to PubMed...
    6. Rybníček O, Seberová E, a kol. Průvodce specifickou alergenovou imunoterapií. Praha: ČIPA, 2009.
    7. Calderon MA, Larenas D, Kleine-Tebbe J, et al. EAACI Position Paper: Dose-response relationship in allergen-specific immunotherapy. Allergy 2011; 66(10): 1345-1369. Go to original source... Go to PubMed...
    8. Calderon MA, Cardona V, Demoly P. One hundred years of allergen immunotherapy. European academy of allergy and clinical immunology celebration: Review of unaswered questions. Allergy 2012; 67(4): 462-476. Go to original source... Go to PubMed...
    9. Phillips EW. Relief of hey-fever by intradermal injections of pollen extract. J Am Med Assoc 1926; 86: 182-184. Go to original source...
    10. Tang MLK, Martino DJ. Oral Immunotherapy and tolerance induction in children. Pediat Allergy Immunol 2013; 24: 512-520. Go to original source... Go to PubMed...
    11. Kägi MK, Wüthrich B. Different methods of local allergen-specific immunotherapy. Allergy 2002; 57: 379-388. Go to original source... Go to PubMed...
    12. Passalacqua G, Canonica GW. Local nasal specific immunotherapy for allergic rhinitis. Allergy, Asthma & Clin Immunol 2006; 2: 117-123. Go to original source... Go to PubMed...
    13. Canonica GW, Bousquet J, Casale T, et al. Sublingual Immunotherapy: World Allergy Organization position paper 2009. World Allergy Organization Journal 2009; 2(11): 223-281. Go to original source... Go to PubMed...
    14. Senti G, von Moos S, Kündig TM. Epicutaneus allergen administration: Is this the future of allergen-specific immunotherapy? Allergy 2011; 66(6): 798-809. Go to original source... Go to PubMed...
    15. Hylander T, Latif L, Petersson-Westin U, et al. Intralymphatic allergen-specific immunotherapy: An efective and safe alternative treatment route for pollen-induced allergic rhinitis. J Allergy Clin Immunol 2013; 131(2): 412-420. Go to original source... Go to PubMed...
    16. Valace DV. Anaphylaxis in the allergist's office: Preparing your office and staff for medical emergencies. Allergy Asthma Proceedings 2013; 34(2): 120-131. Go to original source...
    17. Canonica GW, Cox L, Pawankar R. Sublingual immunotherapy WAO Position Paper 2012 update. In press.
    18. Petrů V. Specifická alergenová imunoterapie v praxi. Alergie 2013; 15(3): 197-202.

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