Pediatr. praxi. 2014;15(6):337-339

Differences in Pharmacokinetics in Children

MUDr.Petra Matalová, Ph.D.1, PharmDr.Jaroslav Matal, Ph.D.2
1 Ústav farmakologie LF UP a FN Olomouc
2 Lékárna FN Olomouc

Human growth and development consists of a continuum of biologic events. The impact of these developmental changes in drug disposition

is largely related to changes in body composition (e.g. body water content, plasma protein concentrations) and function of organs

important in metabolism (e.g. the liver) and excretion (e.g. the kidney). During the first decade of life, these changes are dynamic and

can be nonlinear and discordant making standardized dosing inadequate. During rapid phases of growth/development drug disposition

and response may be altered. The main goal is to optimize drug therapy in children. This can be achieved through fundamental understanding

of how ontogeny influences pharmacokinetics.

Keywords: children, pharmacokinetics, absorption, distribution, excretion

Published: December 16, 2014  Show citation

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Matalová P, Matal J. Differences in Pharmacokinetics in Children. Pediatr. praxi. 2014;15(6):337-339.
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