Pediatr. praxi. 2015;16(3):168-171

New options for treating oral candidiasis in children by using compounded medications

PharmDr.Zbyněk Sklenář, Ph.D., MBA^1,2, MUDr.Vladimír Ščigel, Ph.D., MBA³, MVDr.Mgr.Kateřina Horáčková^2,4

¹ Farmakologický ústav, 1. lékařská fakulta, Univerzita Karlova v Praze

² Fragnerova lékárna U Černého orla, Praha

³ Stomatologická klinika, 1. lékařská fakulta Univerzity Karlovy, Praha

⁴ Katedra analytické chemie, Farmaceutická fakulta UK, Hradec Králové

Oral candidiasis treatment in neonates and infants is still a current issue. Until recently, the therapeutic solution of this disease has been

consisting mainly in using extemporaneously prepared medicinal products in the oromucosal cavity containing non-specific antifungal

agents. Although oromucosal gels and suspensions containing specific antifungal agents are not available as registered products

in the Czech Republic, during the past five years got to enrichment of the portfolio for compounding with new substances. Nystatin

and miconazole are newly available for compounding and even they can be successfully used for the treatment of oromucosal candidiasis

in neonates, infants, children and adults. The paper aim is to inform physicians of treatment possibilities, oromucosal candidiasis

compounded preparations. The paper provides an overview of the available products. It focuses on the new substances - nystatin and

miconazole - and presents the current magistral formulas that can be used for the treatment of oromucosal candidiasis (thrush) and

that could thus completely replace the widely prescribed preparations with gentian (methyl) violet. Presented formulas were created by

the authors, who also checked in practice, the active substance for the extemporaneous preparation are currently available for routine

prescription and yet fully covered by public health insurance.

Keywords: candidiasis, neonates, magistral formulas, extemporaneous preparation, miconazole, nystatin, gentian (methyl) violet

Published: June 30, 2015  Show citation