Pediatr. praxi. 2015;16(4):221-223

Vitamin D in childhood and adolescence - five spheres of influence

MUDr.Božena Kalvachová, CSc.

Endokrinologický ústav, Praha

The biologically active metabolite of vitamin D, the steroid hormone calcitriol, has several roles in the organism. Its antirachitic effect

is well known almost one hundred years while its mechanism has been elucidated later. We consider this systemic regulatory influence

of calcitriol on the calcium-phosphate metabolism as its priority function. Its local creation and regional tissue effectivity of calcitriol

after its binding to cellular nuclear receptors – the endocrine microsystems – build up further spheres of influence: immunomodulation,

metabolic reactions, development and functionality of the brain and fetal programming. Proper care for sufficient substrate for these

microsystems in the developing and growing organism means possible prevention and therapy for many disturbances and illnesses.

Optimally by a natural way or with minimal treatment expenses.

Keywords: calcitriol, myoskeleton, immunomodulation, metabolism, brain, fetal programming, supplementation

Published: September 20, 2015  Show citation