Pediatr. praxi. 2015;16(4):224-226

Anaphylaxis in children - a practial recommendation

doc.MUDr.Vít Petrů, CSc.

Centrum alergologie a klinické imunologie, Nemocnice Na Homolce, Praha

Anaphylaxis is an acute, potentially life-threatening syndrome with multisystemic manifestations due to the rapid release of proinflammatory

mediators. In children, foods can be a significant trigger for anaphylaxis (milk, eggs, wheat, soy, peanuts, fish and others). Patients

experiencing anaphylaxis can present with cutaneous, respiratory, cardiovascular or gastrointestinal manifestations. Epinephrine given

intramusculary remains the mainstay of treatment for this condition. Other second or third-line therapies, such as inhaled beta-2 agonists,

H1 and H2 receptor antagonists and corticosteroids, may play a role in resolving respiratory and cutaneous signs and symptoms. Biphasic

reactions may occur during the resolution phase of symptoms and, thus, all patients should be observed before discharge from hospital.

On discharge, all patients should be prescribed epinephrine autoinjectors, and referred to an allergist for further evaluation and education.

Keywords: anaphylaxis, epinephrine

Published: September 20, 2015  Show citation