Pediatr. praxi 2019; 20(1): 32-34 | DOI: 10.36290/ped.2019.007

Caffeine intoxication accompanied by rhabdomyolysis

MUDr. Jan Papež, MUDr. Jiří Štarha, Ph.D., MUDr. Petr Jabandžiev, Ph.D., prof. MUDr. Zdeněk Doležel, CSc.
Pediatrická klinika LF MU a FN Brno

Caffeine is one of the most commonly used psychoactive substances worldwide. With an adequate intake it is a safe drug, but there
might appear dangerous and even life‑threatening
conditions related to high doses. Rhabdomyolysis might be also a complication
resulting from the acute caffeine intoxication, with a possible progress to acute kidney injury. Authors present a case report of
a teenager with muscle damage as a consequence of having indigested a large amount of caffeine pills.

Keywords: caffeine, intoxication, children

Published: February 22, 2019  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Papež J, Štarha J, Jabandžiev P, Doležel Z. Caffeine intoxication accompanied by rhabdomyolysis. Pediatr. praxi. 2019;20(1):32-34. doi: 10.36290/ped.2019.007.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Abbott PJ. Caffeine: a toxicological overview. Med J Aust. 1986; 145: 518-521. Go to original source... Go to PubMed...
    2. Alazami M, Lin SH, Cheng CJ, Davids MR, Halperin ML. Unusual causes of hypokalaemia and paralysis. QJM. 2006; 99: 181-192. Go to original source... Go to PubMed...
    3. Fredholm BB, Battig K, Holmen J, Nehlig A, Zvartau EE. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev. 1999; 51(1): 83-133. Go to PubMed...
    4. Kaplan GB, Greenblatt DJ, Ehrenberg BL, Goddard JE, Cotreau MM, Harmatz JS, Shader RI. Dose-dependent pharmacokinetics and psychomotor effects of caffeine in humans. J Clin Pharmacol. 1997; 37(8): 693-703. Go to original source... Go to PubMed...
    5. Seifert SM, Schaechter JL, Hershorin ER, Lipshultz SE. Health effects of energy drinks on children, adolscents, and young adults. Pediatrics 2011; 127: 511-528. Go to PubMed...
    6. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2015. Scientific Opinion on the safety of caffeine. EFSA Journal 2015; 13(5): 4102, 120 pp. Go to original source...
    7. Bernard S. Severe lactic acidosis following theophylline overdose. Ann Emerg Med. 1991; 20(10): 1135-1137. Go to original source... Go to PubMed...
    8. Brown MJ, Brown DC, Murphy MB. Hypokalemia from beta2-receptor stimulation by circulating epinephrine. N Engl J Med. 1983; 309: 1414-1419. Go to original source... Go to PubMed...
    9. Judge BS. Differentiating the causes of metabolic acidosis in the poisoned patient. Clin Lab Med. 2006; 26: 31-48. Go to original source... Go to PubMed...
    10. Morita S, Yamagiwa T, Aoki H, Sakurai K, Inokuchi S. Plasma lactate concentration as an indicator of plasma caffeine concentration in acute caffeine poisoning. Acute Med Surg. 2014; 1(3): 159-162. Go to original source... Go to PubMed...
    11. Phillips D, Russell M, Nanayakkara B. Caffeine-induced rhabdomyolysis at a near-toxic dose. Medical Student Journal of Australia. 2012; 4(1): 49-52.
    12. Tajima Y. Coffee-induced hypokalaemia. Clin Med Insights Case Rep 2010; 3: 9-13. Go to original source... Go to PubMed...
    13. Wrenn KD, Oschner I. Rhabdomyolysis induced by a caffeine overdose. Ann Emerg Med. 1989; 18: 94-97 Go to original source... Go to PubMed...
    14. Chen CY, Lin YR, Zhao LL, Yang WC, Chang YJ, Wu HP. Clinical factors in predicting acute renal failure caused by rhabdomyolysis in the ED. Am J Emerg Med 2013; 31: 1062-1066. Go to original source... Go to PubMed...
    15. Winek CL, Wahba WW, Winek CL Jr, Balzer TW. Drug and chemical blood level data 2001. Forensic Sci. Int. 2001; 122: 107-123. Go to PubMed...
    16. Higdon JV, Frei B. Coffee and health: A review of recent human research. Crit. Rev. Food Sci. Nutr. 2006; 46: 101-123. Go to original source... Go to PubMed...
    17. Babu KM, Church RJ, Lewander W. Energy drinks: the new eye-opener for adolescents. Clin Pediatr Emerg Med 2008; 9: 35-42. Go to original source...
    18. Chopra A, Morrison L. Resolution of caffeine-induced complex dysrhythmia with procainamide therapy. J Emerg Med. 1995; 13: 113-117. Go to original source... Go to PubMed...
    19. Price KR, Fligner DJ. Treatment of caffeine toxicity with esmolol. Ann Emerg Med. 1990; 19: 44-46. Go to original source... Go to PubMed...
    20. Emohare O, Ratnam V. Multiple cardiac arrests following an overdose of caffeine complicated by penetrating trauma. Anaesthesia. 2006; 61: 54-56. Go to original source... Go to PubMed...
    21. Ishigaki S, Fukasawa H, Kinoshita-Katahashi N, Yasuda H, Kumagai H, Furuya R. Caffeine intoxication successfully treated by hemoperfusion and hemodialysis. Intern Med 2014; 53: 2745-2747. Go to original source... Go to PubMed...

    Return to the content


    Pediatrics for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.