Pediatr. praxi. 2020;21(1):12-16 | DOI: 10.36290/ped.2020.008

The Pneumococcus - Innocent colonizer or invasive enemy?

MUDr. Zuzana Vančíková, CSc.
KDDL 1. LF UK a VFN Praha

Human beings develop in continual contact with microorganisms. 1-3% of our weight is the mass of microbes we harbor on our mucosas and our organs. The scientific name for them is "microbiota". They have substantial impact on development of our immunity, metabolism, neurological and other functions (1). Their influence on macroorganism is mostly positive, but sometimes they can also cause infection. This balance depends on multiple host and microbe factors. The Pneumococcus normally colonizes nasopharynx of majority of healthy preschool children, but it can also cause invasive infection. Effective prevention of pneumococcal colonization and infection is vaccination. Antibiotic treatment is indicated only to treat infection. It is strictly not recommended to erradicate colonization, which is a physiologic phenomenon!

Keywords: microbiota, Streptococcus pneumoniae, colonization, vaccination.

Accepted: February 23, 2020; Prepublished online: February 23, 2020; Published: March 19, 2020  Show citation

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Vančíková Z. The Pneumococcus - Innocent colonizer or invasive enemy? Pediatr. praxi. 2020;21(1):12-16. doi: 10.36290/ped.2020.008.
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References

  1. Tlaskalová‑Hogenová H, Jirásková Zákostelská Z, Petanová J et. al. Mikrobiota, imunita a imunologicky mediované choroby. Vnitřní Lék. 2019; 65(2): 98-107. Go to original source...
  2. Henriques‑Normak B, Tuomanen EI. The Pneumococcus: Epidemiology, Microbiology and Pathogenesis. Cold Spring Harb Perospect Med 2013; 3: a010215. Go to original source...
  3. Hentrich K, Löfling J, Pathaka, et al. Streptococcus pneumoniae Senses a Human‑like Sialic Acid Profile via the Response Regulator CiaR. Cell Host Microbe. 2016; 14: 20(3): 307-317. Go to original source...
  4. Cherry, JD, Harrison GJ, Kaplan SL, Steinbach WJ, Hoetz PJ. Feigin and Cherry' s Textbook of Pediatric Infectious Diseases. Philadelphia: Elsevier Saunders 2013: 7th edition: 4557 s.
  5. Esposito S, Mari D, Bergamaschini L et al, Pneumococcal colonization in older adults. Immun Ageing. 2016; 13: 2. Go to original source...
  6. Cohen R, Levy C, Bingen E, et al. Impact of 13-valent pneumococcal conjugate vaccine on pneumococcal nasopharyngeal carriage in children with acute otitis media. Pediatr Infect Dis J. 2012; 31: 297-301. Go to original source...
  7. Vančíková Z, Trojánek M. Žemličková H, et al. Pneumococcal urinary antigen positivity in healthy colonized children - is it age dependent? Wiener klinische Wochenschrift 2013; 125: 495-500. Go to original source...
  8. Simell B, Auranen K, Käyhty H, et al, & for the Pneumococcal Carriage Group (PneumoCarr) The fundamental link between pneumococcal carriage and disease. Expert Review of Vaccines. 2012; 11: 7: 841-855. Go to original source... Go to PubMed...
  9. Shouval DS, Greenberg D, Givon‑Lavi N, et al. Site‑specific disease potential of individual Streptococcus pneumoniae serotypes in pediatric invasive disease, acute otitis media and acute conjunctivitis. Pediatr Infect Dis J 2006; 25: 602-607. Go to original source...
  10. Dagan R. Relationship between immune response to pneumococcal conjugate vaccines in infants and indirect protection after vaccine implementation. Expert Review of Vaccines, 2019; 18(6): 641-661. Go to original source... Go to PubMed...
  11. Cohen R, Levy, C, Bingen E. Impact of 13-valent Pneumococcal Conjugate Vaccine on Pneumococcal Nasopharyngeal Carriage in Children With Acute Otitis Media Pediatr Infect Dis J. 2012; 31: 297-301. Go to original source...
  12. Dagan R, Patterson S, Juergens CH, et al. Comparative Immunogenicity and Efficacy of 13-Valent and 7-Valent Pneumococcal Conjugate Vaccines in Reducing Nasopharyngeal Colonization: A Randomized Double‑Blind Trial. Clin Infect, DiS. 2013; 57: 952-962. Go to original source...
  13. Harboe ZB, Dalby T, Weinberger DM, et al. Impact of 13 valent pneumococcal conjugate vaccination in invasive pneumococcal disease incidence and mortality. Clin Inf Dis 2014; 59(8): 1066-1073. Go to original source...
  14. Weinberger DM, Malley R, Lipsitch R. Serotype replacement in disease following pneumococcal vaccination: Adiscussion of the evidence. Lancet 2011; 378(9807): 1962-1973. Go to original source...
  15. Lewnard, JA, Hanage, WP. Making sense of differences in pneumococcal serotype replacement. Lancet Infect Dis 2019; 19: e213-20. Go to original source... Go to PubMed...
  16. Levy C, Ouldali N, Caeymaex L, et. al. Diversity of Serotype Replacement After Pneumococcal Conjugate Vaccine Implementation in Europe. J Pediatr 2019; 213: 252-253e3. Go to original source... Go to PubMed...




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