Pediatr. praxi. 2022;23(3):181-184 | DOI: 10.36290/ped.2022.039

Recurrent aphthous stomatitis in children

doc. MUDr. Romana Koberová, CSc.1, doc. MUDr. Vladimíra Radochová, Ph.D.1, doc. MUDr. Vlasta Merglová, CSc.2
1 Stomatologická klinika LF UK a Fakultní nemocnice v Hradci Králové
2 Stomatologická klinika LF UK a Fakultní nemocnice v Plzni

Recurrent aphthous stomatitis (RAS) is the most common chronic oral mucosal lesion affecting up to 25% of population. The diagnosis is based on well-defined clinical characteristics but the precise aetiology and pathogenesis remains unclear. The treatment of RAS should be based on identification and control of possible predisposing factors. A wide range of topical medicaments is available as antiseptics, anti-inflammatory drugs and corticosteroids. The systemic treatment is indicated in patients with continuous and aggressive manifestation, what is extremely rare in children. The present article provides a review of the current concept and knowledge of the aetiology, pathogenesis, and management of RAS in paediatric population.

Keywords: recurrent aphthous stomatitis, children, pathogenesis, treatment.

Published: June 10, 2022  Show citation

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Koberová R, Radochová V, Merglová V. Recurrent aphthous stomatitis in children. Pediatr. praxi. 2022;23(3):181-184. doi: 10.36290/ped.2022.039.
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References

  1. Rennie JS, Reade PC, Hay KD, Scully C. Recurrent aphthous stomatitis. Br Dent J. 1985;159:361-367. Go to original source... Go to PubMed...
  2. Jurge S, Kuffer R, Scully C, Porter SR. Mucosal disease series. Number VI. Recurrent aphthous stomatitis. Oral Dis. 2006;12:1-21. Go to original source... Go to PubMed...
  3. Barrons RW. Treatment strategies for recurrent oral aphthous ulcers. Am J Health-Syst Pharm. 2001;58:41-50. Go to original source... Go to PubMed...
  4. Belenguer-Guallar I, Jiménez-Soriano Y, Claramunt-Lozano A. Treatment of recurrent aphthous stomatitis. A literature review. J Clin Exp Dent. 2014;6:e168-174. Go to original source... Go to PubMed...
  5. Edgar NR, Saleh D, Miller RA. Recurrent Aphthous Stomatitis: A Review. J Clin Aesthetic Dermatol. 2017;10:26-36.
  6. Najafi S, Yousefi H, Mohammadzadeh M, et al. Association study of interleukin-1 family and interleukin-6 gene single nucleotide polymorphisms in recurrent aphthous stomatitis. Int J Immunogenet. 2015;42:428-431. Go to original source... Go to PubMed...
  7. Tugrul S, Koçyiğit A, Doğan R, et al. Total antioxidant status and oxidative stress in recurrent aphthous stomatitis. Int J Dermatol. 2016;55:e130-135. Go to original source... Go to PubMed...
  8. Albanidou-Farmaki E, Deligiannidis A, Markopoulos AK, Katsares V, Farmakis K, Parapanissiou E. HLA haplotypes in recurrent aphthous stomatitis: a mode of inheritance? Int J Immunogenet. 2008;35:427-432. Go to original source... Go to PubMed...
  9. Wray D, Graykowski EA, Notkins AL. Role of mucosal injury in initiating recurrent aphthous stomatitis. Br Med J Clin Res Ed. 1981;283:1569-1570. Go to original source... Go to PubMed...
  10. Stone OJ. Aphthous stomatitis (canker sores): a consequence of high oral submucosal viscosity (the role of extracellular matrix and the possible role of lectins). Med Hypotheses. 1991;36:341-344. Go to original source... Go to PubMed...
  11. McCartan BE, Lamey PJ, Wallace AM. Salivary cortisol and anxiety in recurrent aphthous stomatitis. J Oral Pathol Med. 1996;25:357-359. Go to original source... Go to PubMed...
  12. Boulinguez S, Cornée-Leplat I, Bouyssou-Gauthier ML, Bedane C, Bonnetblanc JM. [Analysis of the literature about drug-induced aphthous ulcers]. Ann Dermatol Venereol. 2000;127:155-158. Go to PubMed...
  13. Hay KD, Reade PC. The use of an elimination diet in the treatment of recurrent aphthous ulceration of the oral cavity. Oral Surg Oral Med Oral Pathol. 1984;57:504-507. Go to original source... Go to PubMed...
  14. Besu I, Jankovic L, Magdu IU, Konic-Ristic A, Raskovic S, Juranic Z. Humoral immunity to cow's milk proteins and gliadin within the etiology of recurrent aphthous ulcers? Oral Dis. 2009;15:560-564. Go to original source... Go to PubMed...
  15. Porter SR, Scully C, Flint S. Hematologic status in recurrent aphthous stomatitis compared with other oral disease. Oral Surg Oral Med Oral Pathol. 1988;66:41-44. Go to original source... Go to PubMed...
  16. Nolan A, McIntosh WB, Allam BF, Lamey PJ. Recurrent aphthous ulceration: vitamin B1, B2 and B6 status and response to replacement therapy. J Oral Pathol Med. 1991;20:389-391. Go to original source... Go to PubMed...
  17. Natah SS, Konttinen YT, Enattah NS, Ashammakhi N, Sharkey KA, Häyrinen-Immonen R. Recurrent aphthous ulcers today: a review of the growing knowledge. Int J Oral Maxillofac Surg. 2004;33:221-234. Go to original source... Go to PubMed...
  18. Ship II. Epidemiologic aspects of recurrent aphthous ulcerations. Oral Surg Oral Med Oral Pathol. 1972;33:400-406. Go to original source... Go to PubMed...
  19. Miller MF, Garfunkel AA, Ram C, Ship II. Inheritance patterns in recurrent aphthous ulcers: twin and pedigree data. Oral Surg Oral Med Oral Pathol. 1977;43:886-891. Go to original source... Go to PubMed...
  20. Pastore L, Carroccio A, Compilato D, Panzarella V, Serpico R, Lo Muzio L. Oral manifestations of celiac disease. J Clin Gastroenterol. 2008;42:224-232. Go to original source... Go to PubMed...
  21. Butbul Aviel Y, Tatour S, Gershoni Baruch R, Brik R. Colchicine as a therapeutic option in periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome. Semin Arthritis Rheum. 2016;45:471-474. Go to original source... Go to PubMed...
  22. Lin C-M, Wang C-C, Lai C-C, Fan H-C, Huang W-H, Cheng S-N. Genital ulcers as an unusual sign of periodic fever, aphthous stomatitis, pharyngotonsillitis, cervical adenopathy syndrome: a novel symptom? Pediatr Dermatol. 2011;28:290-294. Go to original source... Go to PubMed...
  23. Berk DR, Bayliss SJ. Neutrophilic dermatoses in children. Pediatr Dermatol. 2008;25:509-519. Go to original source... Go to PubMed...
  24. Dhopte A, Naidu G, Singh-Makkad R, Nagi R, Bagde H, Jain S. Psychometric analysis of stress, anxiety and depression in patients with recurrent aphthous Stomatitis-A cross-sectional survey based study. J Clin Exp Dent. 2018;10:e1109-1114. Go to original source... Go to PubMed...
  25. Neville B, Damm DD, Allen, C.M., Bouquot JE. Oral and Maxillofacial Pathology. 3rd ed. St. Louis: Saunders; 2009:968 p.
  26. Scully C, Porter S. Recurrent aphthous stomatitis: current concepts of etiology, pathogenesis and management. J Oral Pathol Med. 1989;18:21-27. Go to original source... Go to PubMed...
  27. Gürkan A, Özlü SG, Altiaylik-Özer P, Kurtul BE, Karacan CD, Şenel S. Recurrent Aphthous Stomatitis in Childhood and Adolescence: A Single-Center Experience. Pediatr Dermatol. 2015;32:476-480. Go to original source... Go to PubMed...
  28. Brooke RI, Sapp JP. Herpetiform ulceration. Oral Surg Oral Med Oral Pathol. 1976;42:182-188. Go to original source... Go to PubMed...
  29. Shashy RG, Ridley MB. Aphthous ulcers: a difficult clinical entity. Am J Otolaryngol. 2000;21:389-393. Go to original source... Go to PubMed...
  30. Tarakji B, Gazal G, Al-Maweri SA, Azzeghaiby SN, Alaizari N. Guideline for the diagnosis and treatment of recurrent aphthous stomatitis for dental practitioners. J Int Oral Health. 2015;7:74-80.
  31. Poleník P. Recidivující aftózní stomatitida u dětí. Pediatr. praxi. 2018;19:146-150. Go to original source...
  32. Brocklehurst P, Tickle M, Glenny A-M, Lewis MA, Pemberton MN, Taylor J, et al. Systemic interventions for recurrent aphthous stomatitis (mouth ulcers). Cochrane Database Syst Rev. 2012;9:CD005411. Go to original source... Go to PubMed...
  33. Volkov I, Rudoy I, Freud T, Sardal G, Naimer S, Peleg R, et al. Effectiveness of vitamin B12 in treating recurrent aphthous stomatitis: a randomized, double-blind, placebo-controlled trial. J Am Board Fam Med. 2009;22:9-16. Go to original source... Go to PubMed...
  34. Chandrasekhar J, Liem AA, Cox NH, Paterson AW. Oxypentifylline in the management of recurrent aphthous oral ulcers: an open clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;87:564-567. Go to original source... Go to PubMed...
  35. Ivančaková R. Recidivující afty a jejich léčba v dětském věku. Pediatr praxi. 2014;15:57.




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