Pediatr. praxi. 2023;24(6):398-402 | DOI: 10.36290/ped.2023.096

Diagnostic significance of postnatal interleukin-6 dynamics in preterm neonates

MUDr. Anna Baštan1, MUDr. Jan Hálek, Ph.D.1, 2, RNDr. Tomáš Fürst, Ph.D.3, prof. MUDr. Vladimír Mihál, CSc.1
1 Dětská klinika, Fakultní nemocnice a Lékařské fakulty Univerzity Palackého Olomouc
2 Novorozenecké oddělení, Fakultní nemocnice Olomouc
3 Katedra matematické analýzy a aplikací matematiky, Přírodovědecká fakulta Univerzita Palackého, Olomouc

Introduction: The aim of this study was to compare interleukin-6 values in umbilical cord and peripheral blood of newborns. The clinical goal was to determine whether the examination of cord blood can replace early postnatal peripheral blood collection.

Patients and methods: Study included premature newborns (< 35th week of gestation) born in 2016-2018 at Olomouc University Hospital. At the same time, it was possible to collect a sufficient amount of blood from the umbilical cord in these newborns.

Results: Paired sampling was successful in 73 of these newborns. A significant difference (p < 0,001) was found between the umbilical cord and peripheral interleukin-6 values. The median of the first measurement (cord blood) was 6,5 ng/l, the median of the second measurement (peripheral blood) was 56 ng/l. The increase is almost ten times bigger.

Conclusion: The difference of values between interleukin-6 from umbilical cord blood and from early postnatal collection are significantly different and it is necessary to keep it in mind during its clinical use.

Keywords: newborn, sepsis, interleukin-6, umbilical cord.

Accepted: November 14, 2023; Published: November 22, 2023  Show citation

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Baštan A, Hálek J, Fürst T, Mihál V. Diagnostic significance of postnatal interleukin-6 dynamics in preterm neonates. Pediatr. praxi. 2023;24(6):398-402. doi: 10.36290/ped.2023.096.
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