Pediatr. praxi. 2024;25(5):329-332 | DOI: 10.36290/ped.2024.064

Acute pericarditis associated with parvovirus infection in a girl with acute lymphoblastic leukemia

prof. MUDr. Vladimír Mihál, CSc.1, 2, MUDr. Alžběta Palátová2, MUDr. Veronika Stará3, MUDr. Olena Jurchenko3, MUDr. Lenka Bakaj-Brožková, Ph.D.4
1 Ústav molekulární a translační medicíny LF UP Olomouc
2 Dětská klinika LF UP a FN v Olomouci
3 Dětské kardiocentrum 2. LF UK a FN Motol, Praha
4 Radiologická klinika LF UP a FN v Olomouci

One week after the end of maintenance treatment, acute parvovirus B19 infection was confirmed by DNA in the blood of an 11-year-old girl with acute lymphoblastic leukaemia Clinical manifestations were two weeks of fever, moist cough, and intermittent chest pain on inspiration. Elevated serum CRP, N-terminal natriuretic peptide, but slightly elevated troponin values were detected. The ECG recording showed strikingly low P-wave, QRS complex and T-wave voltages. Echocardiographic examination confirmed acute myopericarditis with extensive pericardial effusion. The patient's recovery, supported by diuretic therapy and corticosteroids was prompt, with complete reduction of the pericardial effusion after one week treatment.

Keywords: child, acute lymphoblastic leukemia, maintenance therapy, acute pericarditis, parvovirus B19.

Accepted: October 21, 2024; Published: November 15, 2024  Show citation

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Mihál V, Palátová A, Stará V, Jurchenko O, Bakaj-Brožková L. Acute pericarditis associated with parvovirus infection in a girl with acute lymphoblastic leukemia. Pediatr. praxi. 2024;25(5):329-332. doi: 10.36290/ped.2024.064.
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    References

    1. Cossart YE, Field AM, Cant B, et al. Parvovirus-like particles in human sera. Lancet. 1975;1(7898):72-73. Go to original source... Go to PubMed...
    2. Leung AKC, Lam JM, Barankin B, et al. Erythema Infectiosum: A narrative review. Curr Pediatr Rev. 2024;20(4):462-471. Go to original source... Go to PubMed...
    3. Bassols AC. Parvovirus B19 and the new century. Clin Infect Dis. 2008;46(4):537-539. Go to original source... Go to PubMed...
    4. Bültmann BD, Klingel K, Sotlar K, et al. Parvovirus B19: a pathogen responsible for more than hematologic disorders. Virchows Arch. 2003;442(1):8-17. Go to original source... Go to PubMed...
    5. Morey AL, Keeling JW, Porter HJ, et al. Clinical and histopathological features of parvovirus B19 infection in the human fetus. Br J Obstet Gynaecol. 1992;99(7):566-574. Go to original source... Go to PubMed...
    6. Lindblom A, Heyman M, Gustafsson I, et al. Parvovirus B19 infection in children with acute lymphoblastic leukemia is associated with cytopenia resulting in prolonged interruptions of chemotherapy. Clin Infect Dis. 2008;46(4):528-536. Go to original source... Go to PubMed...
    7. Mihál V, Dusek J, Hajdúch M, et al. Transient aplastic crisis in a leukemic child caused by parvovirus B19 infection. Pediatr Hematol Oncol. 1996;13(2):173-177. Go to original source... Go to PubMed...
    8. Imazio M, Cecchi E, Demichelis B, et al. Myopericarditis versus viral or idiopathic acute pericarditis. Heart. 2008;94: 498-501. Go to original source... Go to PubMed...
    9. Krasic S, Prijic S, Ninic S, et al. Predictive factors of recurrence after pediatric acute pericarditis. J Pediatr (Rio J). 202197(3):335-341. Go to original source... Go to PubMed...
    10. Verdonschot J, Hazebroek M, Merken J, et al. Relevance of cardiac parvovirus B19 in myocarditis and dilated cardiomyopathy: review of the literature. Eur J Heart Fail. 2016;(12): 1430-1441. Go to original source... Go to PubMed...
    11. Vigneswaran TV, Brown JR, Breuer J, et al. Parvovirus B19 myocarditis in children: an observational study. Arch Dis Child. 2016;101(2):177-180. Go to original source... Go to PubMed...
    12. Ratnapalan S, Brown K, Benson L. Children presenting with acute pericarditis to the emergency department. Pediatr Emerg Care. 2011;27(7):581-585. Go to original source... Go to PubMed...
    13. Esmel-Vilomara R, Dolader P, Izquierdo-Blasco J, et al. Parvovirus B19 myocarditis in children: a diagnostic and therapeutic approach. Eur J Pediatr. 2022;181(5):2045-2053. Go to original source... Go to PubMed...
    14. Keramari S, Poutoglidis A, Chatzis S, et al. Parvovirus B19-associated myocarditis: a literature review of pediatric cases. Cureus. 2022;14(1):e21726. doi: 10.7759/cureus.21726. PMID: 35251800; PMCID: PMC8886913. Go to original source... Go to PubMed...
    15. Adler Y, Charron P, Imazio M, et al. ESC Scientific Document Group. 2015 ESC Guidelines for the diagnosis and management of pericardial diseases: The Task Force for the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology (ESC) Endorsed by: The European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2015;36(42):2921-2964. Go to original source... Go to PubMed...
    16. Peterson TA, Turner SP, Dolezal KA. Acute Pericarditis: Rapid Evidence Review. Am Fam Physician. 2024;109(5):441-446.
    17. Backhoff D, Steinmetz M, Ruschewski W, et al. Severe constrictive pericarditis after parvovirus B19 and human herpes virus 6 infection in a 9-year-old girl. Pediatr Cardiol. 2013;34(8):2089-2092. Go to original source... Go to PubMed...
    18. Koehl B, Oualha M, Lesage F, et al. Fatal parvovirus B19 myocarditis in children and possible dysimmune mechanism. Pediatr Infect Dis J. 2012;31(4):418-421. Go to original source... Go to PubMed...
    19. van Diepen KM, de Almeida CL, Kam AJ. An interesting case of viral pericarditis. Pediatr Emerg Care. 2016;32(5):323-325. Go to original source... Go to PubMed...

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