Pediatr. praxi. 2025;26(1):24-26 | DOI: 10.36290/ped.2025.005
Transient hypogamaglobulinemia of infancy
- 1 Dětská klinika, Fakultní nemocnice Plzeň, Univerzita Karlova, Lékařská fakulta v Plzni
- 2 Oddělení revmatologie dětí a dospělých, Fakultní nemocnice Motol, Praha
- 3 Ústav imunologie a alergologie, Fakultní nemocnice Plzeň, Univerzita Karlova, Lékařská fakulta v Plzni
Transient hypogammaglobulinemia is a relatively common primary antibody immunodeficiency in infants and toddlers with a wide clinical picture. The pathophysiological basis is a delayed onset of the production of own immunoglobulins, resulting in a temporary decrease in serum IgG concentration in the infant. THI usually resolves spontaneously between the ages of 2 and 6 years. In the laboratory, a reduced serum IgG concentration (possibly also IgA and IgM) dominates with a normal representation of B-lymphocytes. In the differential diagnosis, we also consider other immunodeficiencies. Interdisciplinary cooperation is very important.
Keywords: THI, etiopathogenesis, clinical evaluation, differential diagnosis, treatment.
Accepted: March 6, 2025; Published: March 19, 2025 Show citation
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References
- Bellutti Enders F, Conti F, Candotti F, et al. Transient hypogammaglobulinemia of infancy. Rev Med Suisse. 2017; 13(557):739-742.
- Palmeira P, Quinello C, Silveira-Lessa AL, et al. IgG placental transfer in healthy and pathological pregnancies. Clin Dev Immunol. 2012; 2012:985646. doi: 10.1155/2012/985646. Epub 2011 Oct 1. PMID: 22235228; PMCID: PMC3251916.
Go to original source... 
Go to PubMed... - Siemińska I, Rutkowska-Zapała M, Bukowska-Strakova K, et al. The level of myeloid-derived suppressor cells positively correlates with regulatory T cells in the blood of children with transient hypogammaglobulinaemia of infancy. Cent Eur J Immunol. 2018;43(4):413-420. Go to original source... Go to PubMed...
- Dancis J, Osborn JJ, Kunz HW. Studies of immunology of the newborn infant, IV: Antibody formation in the premature infant Pediatrics. 1953;12:151-157. Go to original source...
- Keles S, Artac H, Kara R, et al. Transient hypogammaglobulinemia and unclassified hypogammaglobulinemia: 'similarities and differences'. Pediatr Allergy Immunol. 2010;21(5):843-851. doi: 10.1111/j.1399-3038.2010.01010.x. Epub 2010 Jul 1. PMID: 20609138. Go to original source... Go to PubMed...
- Justiz-Vaillant AA, Hoyte T, Davis N, et al. A Systematic Review of the Clinical Diagnosis of Transient Hypogammaglobulinemia of Infancy. Children (Basel). 2023;10(8):1358. doi: 10.3390/children10081358. PMID: 37628357; PMCID: PMC10453633. Go to original source... Go to PubMed...