Pediatr. praxi. 2025;26(1):33-36 | DOI: 10.36290/ped.2025.007

Pharmacologically induced gynecomastia in pediatric patients: a review of the most common medications

MUDr. Júlia Bartková, MBA, MPH^{1, 2}, Joachim Pilin³, Jan Tkáč², Marianna Kotradyová²

¹ Klinika popálenin a plastické chirurgie, FN Brno

² Lékařská fakulta Masarykovy univerzity Brno

³ III. lékařská fakulta Univerzita Karlova Praha

Gynecomastia is a benign enlargement of breast tissue in males that can have significant psychological impacts, especially in children and adolescents. This article focuses on pharmacologically induced gynecomastia and the most common medications that may contribute to its development. In our analysis, we identified and examined relevant studies and case reports published in the PubMed database that discuss various aspects of gynecomastia in pediatric patients. An important step in the prevention of gynecomastia is the awareness of healthcare professionals, parents, and patients regarding the potential risks associated with the use of certain medications. It is essential that all possible side effects are considered when prescribing treatment and that a thorough assessment of the benefits and risks is conducted. Additionally, it is recommended to carry out regular check-ups and evaluations of patients who are taking high-risk medications to identify and address any symptoms of gynecomastia in a timely manner. This article emphasizes the need for increased attention to selected medications commonly cited in the scientific literature and a multidisciplinary approach to treatment. Awareness of pharmacological risks and support from healthcare professionals are crucial for the prevention and management of this condition, as well as for the psychological well-being of pediatric patients suffering from this diagnosis.

Keywords: gynecomastia, benign breast tissue enlargement, pediatric gynecomastia, drug-induced gynecomastia.

Accepted: March 6, 2025; Published: March 19, 2025  Show citation