Pediatr. praxi. 2025;26(4):246-248 | DOI: 10.36290/ped.2025.048

How an infection revealed a congenital disease

MUDr. Petr Birke1, MUDr. Barbora Ludíková, Ph.D.1, MUDr. Lenka Bakaj Zbrožková, Ph.D.2
1 Dětská klinika LF Univerzity Palackého v Olomouci a FN Olomouc
2 Radiologická klinika LF Univerzity Palackého v Olomouci a FN Olomouc

Parvovirus B19 not only causes erythema infectiosum, it can also cause myocarditis, arthralgias and/or arthritis, and can cause hydrops fetalis, pure red blood cell aplasia in immunocompromised individuals, and finally transient aplastic crisis in patients with congenital hemolytic anemias. We present the case of a boy who was diagnosed with hereditary spherocytosis at the age of six due to parvovirus B19 infection.

Keywords: congenital hemolytic anemia, hereditary spherocytosis, parvovirus B19, transient aplastic crisis, cholelithiasis.

Accepted: August 20, 2025; Published: September 26, 2025  Show citation

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Birke P, Ludíková B, Bakaj Zbrožková L. How an infection revealed a congenital disease. Pediatr. praxi. 2025;26(4):246-248. doi: 10.36290/ped.2025.048.
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    References

    1. . Iolascon A, Miraglia del Giudice E, Perrotta S, et al. Hereditary spherocytosis: from clinical to molecular defects. Haematologica. 1998;83(3):240-257.
    2. . Polizzi A, Dicembre LP, Failla C, et al. Overview on Hereditary Spherocytosis Diagnosis. Int J Lab Hematol. 2025;47(1):18-25. Go to original source... Go to PubMed...
    3. . Risinger M, Kalfa TA. Red cell membrane disorders: structure meets function. Blood. 2020;136(11):1250-1261. Go to original source... Go to PubMed...
    4. . Andolfo I, Russo R, Gambale A, et al. New insights on hereditary erythrocyte membrane defects. Haematologica. 2016;101(11):1284-1294. doi: 10.3324/haematol.2016.142463. Go to original source... Go to PubMed...
    5. . Kalfa TA. Diagnosis and clinical management of red cell membrane disorders. Hematology Am Soc Hematol Educ Program. 2021;2021(1):331-340. Go to original source... Go to PubMed...
    6. . Bolton-Maggs PH, Langer JC, Iolascon A, et al. Guidelines for the diagnosis and management of hereditary spherocytosis - 2011 update. Br J Haematol. 2012;156(1):37-49. Go to original source... Go to PubMed...
    7. . Mortimer PP. Hypothesis: the aplastic crisis of hereditary spherocytosis is due to a single transmissible agent. J Clin Pathol. 1983;36(4):445-448. Go to original source... Go to PubMed...
    8. . Kelleher JF Jr, Luban NL, Cohen BJ, et al. Human serum parvovirus as the cause of aplastic crisis in sickle cell disease. Am J Dis Child. 1984;138(4):401-403. Go to original source... Go to PubMed...
    9. . Perrotta S, Gallagher PG, Mohandas N. Hereditary spherocytosis. Lancet. 2008;372(9647):1411-1426. Go to original source... Go to PubMed...
    10. . Kellermayer R, Faden H, Grossi M. Clinical presentation of parvovirus B19 infection in children with aplastic crisis. Pediatr Infect Dis J. 2003;22(12):1100-1101. Go to original source... Go to PubMed...

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