Pediatr. praxi. 2007;8(6):369-373
Current therapy of inflammatory bowel diseases in children
- I. dětská klinika UK 2. LF a FN Motol, Praha
The aim of the article is to familiarize clinicians and other practitioners with the therapy of IBD in children, emphasizing the role of medications in induction and maintenance. The modern molecular techniques have made possible the production of highly specific monoclonal antibodies to target particular cellular and humeral mediators of mucosal inflammation. Infliximab was the first agent of this class to demonstrate clinical efficacy for the treatment of patients with IBD. This modern biological treatment is used in patients with corticosteroid-resistant or fistulizing disease. Gastroenterologist carrying for children with IBD must develop an optimal regimen of pharmacologic therapies, nutritional management, psychological support and properly timed surgery (when necessary) that will maintain disease remission.
Keywords: inflammatory bowel disease in children, ulcerative colitis, Crohn’s disease, biological therapy
Published: January 20, 2008 Show citation
References
- Belluzzi A, Brignola C, Campieri M et al. Effect of an enteric-coated fish-oil preparation on relapses in Crohn´s disease. N Engl J Med 1996; 334: 1557-1560.
Go to original source... 
Go to PubMed... - Day AS, Whitten KE et al. Exclusive enteral feeding as primary therapy for Crohn´s disease in Australian children and adolescents: a feasible and effective approach. J Gastroenterol Hepatol 2006; 21: 1609-1614. Go to original source... Go to PubMed...
- De Ridder L, Benninga A, Taminiau J et al. Infiliximab use in children and adolescents with inflammatory bowel disease J Pediatr Gastroenterol Nutr 2007; 45: 3-14. Go to original source... Go to PubMed...
- Gionchetti P, Rizello F, Helwig U et al. Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial. Gastroenterology 2003; 124: 1202-1209. Go to original source... Go to PubMed...
- Hanauer SB, Sandborn WJ, Rutgeerts P et al. Human anti-tumor necrosis factor monoclonal antibody (adalimubab) in Crohn´s disease: the CLASSIC-1 trial. Gastroenterology 2006; 130: 323-333. Go to original source... Go to PubMed...
- Heuschekel RB, Menache CC et al. Enteral nutrition and corticosteroids in the treatment of a acute Crohn´s disease in children. J Pediatr Gastroenterol Nutr 2000; 31: 8-15. Go to original source... Go to PubMed...
- Johnson T, Macdonald S, Hill M et al. Treatment of active Crohn´s disease in children using partila enteral nutrition with liquid formula: a randomised controlled trial. Gut 2006; 55: 356-361. Go to original source... Go to PubMed...
- Kruis W, Schulz E, Frič P et al. Double blind comparison of an oral Escherichia coli preparation and in maintaining remission of ulcerative colitis. Aliment Pharmacol Ther 1997; 11: 853-858. Go to original source... Go to PubMed...
- Loeschke K, Ueberschaer B, Pietsch A et al. N-3 faty acids only delay early relapses of ulcerative colitis in remission. Dig Dis Sci 1996; 41: 2087-2094. Go to original source... Go to PubMed...
- Prescott S, Stenson W. Fish oil fix. Nature Medicine 2005; 11: 596-598. Go to original source... Go to PubMed...
- Rufo PA, Bousvaros A. Current therapy of inflammatory bowel disease in children. Pediatr Drugs 2006; 8: 280-302. Go to original source... Go to PubMed...
- Travis SPL, Stange EF, Lémann M et al. European evidence based consensus on the diagnosis and management of Crohn´s disease: current management. Gut 2006; 55: i16-i35. Go to original source... Go to PubMed...
- Wild E, Drozdowski L, Tartaglia C et al. Nutritional modulation of the inflammatory response in inflammatory bowel disease - from molecular to the integrative to the clinical. World J. Gastroenterol 2007; 13: 1-7. Go to original source... Go to PubMed...
- Wilschanski M, Sherman P, Pencharz et al. Suplementary enteral nutrition maintains remission in paediatric Crohn´s disease. Gut 1996; 38: 543-548. Go to original source... Go to PubMed...