Pediatr. praxi. 2013;14(1):18-20

Otolaryngologic manifestations of primary immunodeficiencies

MUDr.Karol Zeleník, Ph.D.^1,2, doc.MUDr.Pavel Komínek, Ph.D., MBA¹

Otorinolaryngologická klinika, Fakultní nemocnice Ostrava

Upper aerodigestive tract is the most common route of entry of microorganisms into the body and the first site of interaction of microorganism

and human immune system. If the immune system is working properly, protects the body from severe consequences of inflammation

in the nose, ears, pharynx and larynx, and also from the penetration of infection into the deeper areas and the resulting complications.

Primary immunodeficiencies very often manifest themselves in the upper aerodigestive tract. In this case, infections tend to be more

severe, the treatment takes longer, complications are more common and the progression to the chronic stage (chronic rhinosinusitis with/

without nasal polyposis, chronic secretory otitis, chronic pharyngolaryngitis and others) can be seen more often, as well. Pediatrician or

otolaryngologist can significantly contribute to early diagnosis and improved patients prognosis if they are aware of potential primary

immunodeficiency in such cases and the patient is directed at the immunological tests.

Keywords: primary immunodeficiency, chronic rhinosinusitis, chronic otitis, absces

Published: February 15, 2013  Show citation