Pediatr. praxi. 2015;16(1):12-16
Thyroid associated orbitopathy in children
- Endokrinologický ústav, Praha
Thyroid associated orbitopathy is a chronic eyes disease associated with autoimmune reaction against the thyroid gland. Chronic
inflammation affectes all orbital structures- orbital fat and connective tissue, extraocular muscles, tear glands and orbital septum.
Increasing orbital volume cases eye replacement, disorder of the venous outflow and causes changes of the muscle elastic properties
which in turn start pulling the eyeball backwards. The patients with Graves-Basedow tyreotoxikosis are most often occured, less in
the chronic autoimmune thyroiditis. Incidence of the thyroid associated orbitopathy isn´t so frequent in children as in adults, the
forms aren´t so serious. Prompt and correct diagnosis, quick arrangement of the thyroid gland function, assessment of the activity
and seriousness of Graves orbitopathy and correct therapy is essential for other prognosis in children. A complex approach is for
treating EO necessary. The European Group of Graves´ Orbitopathy (EUGOGO) recommends that patiens should be treated in specialized
centres.
Keywords: Graves orbitopathy, thyroid associated orbitopathy, Graves hyperthyroidism
Published: February 1, 2015 Show citation
References
- Lavard L, Ranlov I, et al. Incidence of juvenile tyreotoxicosis in Denmark 1982-1988. A nationwide study.EJE 1994; 130: 565-568.
Go to original source... 
Go to PubMed... - Bartley GB, Fatourechi V. The incidence of Graves' ophthalmopathy in Olmsted County. Minnesota.Am J. of Ophthalmopathy 1995; 120: 511-517. Go to original source... Go to PubMed...
- Dutta MK, Gundgurthi A, Garg MK, Kotwal N. Juvenile Graves' disease with opthalmopathy, lymphadenopathy, accelerated growth and congestive cardiac failure. Indian J Pediatr. 2012; 79(5): 670-672. Go to original source... Go to PubMed...
- Krassas GE, Segni M, Wiersinga WM. Childhood Graves' ophthalmopathy: results of a European questionnaire study. Eur J Endocrinol. 2005; 153(4): 515-521. Go to original source... Go to PubMed...
- Hrdá P, Novák Z, Šterzl I. Endokrinní orbitopatie. Farmakoterapie pro praxi/Sv.41, Praha Maxdorf, 2009: 109.
- Mourits MP, Koornneef L, Wiersinga WM, et al. Clinical criteria for the assessment of disease activity in Graves'ophthalmopathy: a novel approach. Br.J Ophthalmol 1989; 73: 639-644. Go to original source... Go to PubMed...
- Gogakos A, Boboridis K, Krassas GE. Pediatric aspects in Graves'orbitopathy. Pediatr Endocrinol Rev. 2010; 7(Suppl 2): 234-244. Go to PubMed...
- Bartalena L, Baldeschi L, Dickinson A, et al. European Group on Graves' Orbitopathy (EUGOGO). Consensus statement of the European Group on Graves' Orbitopathy of management of Graves' Orbitopathy. Eur J Endocrinol. 2008; 158(3): 273-285. Go to original source... Go to PubMed...
- Krassas GE. Wiersinga W. Smoking and autoimmune thyroid dinase: the plot thckens. Eur J Endocrinol. 2006; 154(6): 777-780. Go to original source... Go to PubMed...
- Krassas GE, Perros P. Prevention of thyroid associated-ophthalmopathy in children and adults: current views and management of preventable risk factors. Pediatr Endocrinol Rev. 2007; 4(3): 218-224. Go to PubMed...
- Krassas GE, Gogakos A. Thyroid-associated ophthalmopathy in juvenile Graves' disease-clinical, endocrine and therapeutic aspects. J Pediatr Endocrinol Metab. 2006; 19(10): 1193-206. Go to original source... Go to PubMed...