Pediatr. praxi. 2021;22(5):342-345 | DOI: 10.36290/ped.2021.072

Invasive candidiasis as a life-threatening complication in a child with acute lymphoblastic leukemia

MUDr. Gabriela Matznerová¹, MUDr. Mgr. Tomáš Kuhn, MBAce^{1, 2}, MUDr. Bohumír Blažek¹, MUDr. Tomáš Zaoral, Ph.D.^{1, 2}, Mgr. Radim Dobiáš, Ph.D.^{3, 4}, doc. MUDr. Michal Hladík, Ph.D.^{1, 2}

¹ Klinika dětského lékařství, Fakultní nemocnice Ostrava

² Lékařská fakulta, Ostravská univerzita

³ Oddělení bakteriologie a mykologie, Zdravotní ústav se sídlem v Ostravě

⁴ Katedra biomedicínských oborů, Lékařská fakulta, Ostravská univerzita

Acute lymphoblastic leukemia (ALL) represents 25 % of childhood tumors and it´s the most frequent cancer in children. ALL treatment is based on combined chemotherapy. Long-lasted treatment is now achieved in up to 90 % of patients. The disease is accompanied by a number of complications. The most prevalent complications include bacterial and fungal infections caused by common and opportunistic pathogens. Fungal infections make up 40 % of all infectious complications. We present the case of a 2year-old girl of Asian origin with manifestations of invasive candidiasis diagnosed during the induction phase of treatment of ALL complicated by life-threatening multiorgan failure.

Keywords: acute lymphoblastic leukemia, children, treatment, infectious compliacations, invasive fungal infections.

Published: October 13, 2021  Show citation