Pediatr. praxi. 2023;24(1):59-61 | DOI: 10.36290/ped.2023.022

Peripubertal asymmetric enlargement of labium majus

prof. MUDr. Vladimír Mihál, CSc.1, 2, doc. MUDr. Jiřina Zapletalová, Ph.D.2, MUDr. Jakub Čivrný, Ph.D.3
1 Ústav molekulární a translační medicíny, LF UP Olomouc
2 Dětská klinika, LF UP a FN v Olomouci
3 Radiologická klinika, LF UP a FN v Olomouci

CALME is a non-neoplastic enlargement of normal vulvar soft tissue in response to prepubertal hormonal stimulation resembling unilateral breast enlargement. The prognosis is good and biopsy or surgical treatment is not necessary. We present a 13-year-old pubertal girl who observed gradual enlargement of the right labia at the age of 11 years and two months. Unilateral labium majus hypertrophy without inflammatory and neoplastic features was diagnosed as pediatric asymmetric labia majora enlargement (CALME) after ultrasound and MR examination.

Keywords: assymetric labium majus enlargement, CALME, vulva, pre/puberta.

Accepted: February 7, 2023; Published: February 20, 2023  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Mihál V, Zapletalová J, Čivrný J. Peripubertal asymmetric enlargement of labium majus. Pediatr. praxi. 2023;24(1):59-61. doi: 10.36290/ped.2023.022.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Iwasa Y, Fletcher CD. Distinctive prepubertal vulval fibroma: A hitherto unrecognized mesenchymal tumor of prepubertal girls: Analysis of 11 cases. Am J Surg Pathol. 2004;28:1601-1608. Go to original source... Go to PubMed...
    2. Vargas SO, Kozakewich HP, Boyd TK, et al. Childhood asymmetric labium majus enlargement: mimicking a neoplasm. Am J Surg Pathol. 2005;29(8):1007-1016. Go to original source...
    3. Altchek A, Deligdisch L, Norton K, et al. Prepubertal unilateral fibrous hyperplasia of the labium majus: report of eight cases and review of the literature. Obstet Gynecol. 2007;110(1):103-108. Go to original source... Go to PubMed...
    4. Coutant-Foulc P, Lewis FM, Berville S, et al. Unilateral vulval swelling in cyclists: a report of 8 cases. J Low Genit Tract Dis. 2014 Oct;18(4):e84-89. Go to original source... Go to PubMed...
    5. Suenaga S, Matsumoto F, Kondo F, et al. Unilateral Fibrous Hyperplasia of the Labium Majus in Pre- and Early Pubertal Girls: A Report on 3 Cases. J Pediatr Adolesc Gynecol. 2022;35(2):174-176. Go to original source... Go to PubMed...
    6. Farage MA, Maibach HI. Morphology and physiological changes of genital skin and mucosa. Curr Probl Dermatol. 2011;40:9-19. Go to original source... Go to PubMed...
    7. Gokli A, Neuman J, Lukse R, et al. Childhood asymmetrical labium majus enlargement sonographic and MR imaging appearances. Pediatr Radiol. 2016;46(5):674-679. Go to original source... Go to PubMed...
    8. Salvatori C, Testa I, Prestipino M, et al. Childhood Asymmetry Labium Majus Enlargement (CALME): Description of Two Cases. Int J Environ Res Public Health. 2018;15(7):1525. doi: 10.3390/ijerph15071525. PMID: 30029490; PMCID: PMC6069501. Go to original source... Go to PubMed...
    9. Sechi A, Patrizi A, Vara G, et al. Keep CALME (childhood asymmetry labium majus enlargement) and follow up. J Dtsch Dermatol Ges. 2021;19(9):1276-1281. Go to original source... Go to PubMed...

    Return to the content


    Pediatrics for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.