Pediatr. praxi. 2024;25(6):367-371 | DOI: 10.36290/ped.2024.070

Tubulointerstitial nephritis

MUDr. Patrik Konopásek1, 2
1 Klinika dětí a dorostu 3. lékařské fakulty Univerzity Karlovy a Fakultní nemocnice Královské Vinohrady, Praha
2 2. lékařská fakulta Univerzity Karlovy, Praha

Tubulointersticial nephritis (TIN) is a frequent cause of acute kidney injury. Establishing the diagnosis is often delayed due to its nonspecific symptoms and results of laboratory methods. Drug-induced TIN is the most frequent form of TIN, followed by systemic diseases, and infections. Spontaneous resolution often occurs without the need for extensive examination or treatment, especially when a thorough medical history is obtained and the medication associated with TIN is discontinued early. However, kidney biopsy, along with extensive examinations, is sometimes necessary to determine the etiology of TIN. Patients with acute TIN who do not show spontaneous improvement after removal of causative insult are treated with corticosteroids, whereas immuno­suppressive treatment is usually not indicated for those with chronic TIN. In such cases, management focuses primarily on treating complications of chronic kidney disease, aiming to slow disease progression.

Keywords: acute kidney injury, tubulointerstitial nephritis.

Accepted: December 10, 2024; Published: December 31, 2024  Show citation

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Konopásek P. Tubulointerstitial nephritis. Pediatr. praxi. 2024;25(6):367-371. doi: 10.36290/ped.2024.070.
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